Flow-based Enhancement of Specificity for Label-free Biochemical Assays
A label-free biochemical assay, in which label-free interrogation of a target-receptor layer is performed while the target-receptor layer is subjected to a relatively strong flow of an analyte-containing fluid. The volumetric flow rate for the assay is selected based on calibration data corresponding to the target substance, which advantageously results in fewer and/or smaller false-positive signals corresponding to non-target substances compared to those produced with the fluid being stationary. In various embodiments, the label-free interrogation method can be electro-mechanical and/or optical.
SHIH WAN Y [US]; SHIH WEI-HENG [US]; MCGOVERN JOHN-PAUL [US]
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