Large Scale Microbial Culture Method
A new culture method for producing high levels of a metabolite, such as succinic acid uses oxygen rich culture without pH adjustment to increase the biomass, acclimation in under oxygen lean conditions having <5% partial pressure of oxygen, and the production of high levels of succinate under oxygen deprived conditions. The method can be performed in a single reactor, and is amenable to efficient scale up.
SEGUEILHA LAURENT [FR]; SAN KA-YUI [US]; BENNETT GEORGE [US]; MARTINEZ IRENE [US]
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