Therapeutic Compositions and Methods for Delivery of Active Agents Cleavably Linked to Nanoparticles
Various embodiments of the present invention pertain to therapeutic compositions that comprise: (1) an active agent (e.g., paclitaxel); and (2) a nanoparticle (e.g., gold nanoparticle). In such embodiments, the active agent is covalently linked to the nanoparticle through a cleavable linker (e.g., a linker containing a hyadrazone species). Other embodiments of the present invention pertain to methods of treating a condition in a subject by administering the above-described therapeutic compositions to the subject.
ZUBAREV EUGENE [US]; GIBSON JACOB [US]
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