Non-Natural Peptides as Models for the Development of Antibiotics
Described herein are methods of screening one of the RNA hairpins in the small ribosomal subunit of bacteria to identify peptides that bind to it. The RNA hairpin target may be the 970 loop (aka helix 31 (h31)) or a modified version thereof. The identified peptides may inhibit protein synthesis and, therefore, may be used as a model for new antibiotics.
CUNNINGHAM PHILIP R [US]; CHOW CHRISTINE SHARON [US]; ABEYDEERA NUWAN DINUKA [US]; LAMICHHANE TEK NARAYAN [US]
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