Dendrimer Based Nanodevices for Therapeutic and Imaging Purposes
A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAM AM dendrimer and at least one therapeutically active agent attached to the PAM AM dendrimer. A method of site-specific delivery of a therapeutically active agent, by attaching a therapeutically active agent to a PAM AM dendrimer using a disulfide bond, administering the PAMAM dendrimer to a patient in need of treatment, localizing the dendrimer to a site in need of treatment, and releasing the therapeutically active agent at the site in need of treatment.
KANNAN RANGARAMANUJAM M [US]; KANNAN SUJATHA [US]; ROMERO ROBERTO [US]
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