The invention provides compounds of the formula: wherein X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.
HORWITZ JEROME P [US]; CORBETT THOMAS H [US]; PALOMINO EDUARDO [US]; POLIN LISA [US]; HAZELDINE STUART T [US]
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