Method for Analyzing Biological Networks
Methods and systems for predicting the significance of a biological pathway in a disease state, the method and system comprising: (a) providing data on the expression levels of a plurality of biomolecules differentially expressed in a disease state as compared with the same biomolecules expressed in a non-diseased state within the pathway: (b) determining the probability of the presence of the plurality of biomolecules in said diseased state; (c) determining the effect of each biomolecule from the plurality of biomolecules on the expression of different downstream biomolecules within the pathway thereby providing a perturbation factor for each biomolecule in the pathway; (d) combining the statistical significance of the differentially expressed biomolecule within the pathway present in the disease state with a sum of perturbation factors for all of the biomolecules in the pathway to generate an impact factor for the pathway relevant to the disease state; (e) calculating the statistical significance of the impact factor based upon a determined probability of having a statistical significant presence of differentially expressed biomolecules in step (b) and the sum of perturbation factors within the pathway in step (c); and (f) outputting the statistical significance of the impact factor for the pathway relevant to the disease for a user.
DRAGHICI SORIN [US]
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