Detecting and Sorting Methylated Dna Using a Synthetic Nanopore

Provided are methods for detecting, characterizing or separating DNA based on methylation. Heterogeneous DNA populations are separated based on DNA methylation by providing a membrane having a nanopore through which an electric field is applied. DNA of interest is introduced, and for a given threshold voltage across the nanopore, only DNA having a methylation parameter of interest may transit the pore, thereby facilitating detection, characterization, or separation of DNA based on methylation. The methods are optionally used to detect a disease state that is associated with DNA methylation including, but not limited to, cancer.

Attached files:
WO 2010080617.jpg

Patents:
WO 2,010,080,617

Inventor(s): TIMP GREGORY [US]; TIMP WINSTON [US]; FEINBERG ANDREW [US]; MIRSAIDOV UTKUR [US]

Type of Offer: Licensing



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