Methods for Diagnosing and Treating Pelvic Pain Disorders Via Beta-catenin
Methods for diagnosing a pelvic pain disorder that include analyzing samples for increased levels and/or nuclear accumulation of beta-catenin, which indicates presence of the pelvic pain disorder, particularly interstitial cystitis. Therapeutic treatment of a pelvic pain disorder, particularly interstitial cystitis, includes the administration to a patient of an effective amount of an inhibitor of beta- catenin activity. This can be carried out by direct administration of the therapeutic agent or via gene therapy.
REEDER JAY E [US]; MAYER ROBERT D [US]; O'CONNELL MARY [US]
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