Detection of Fragments of Nectin-1 for the Diagnosis of Alzheimer's Disease
Methods for diagnosing Alzheimer's Disease by detection of fragments of nectin-1 are described. Nectin-1 is shown to be a substrate for proteases associated with the onset of Alzheimer's Disease, including [alpha]-secretase, [gamma]-secretase and BACE1 or a BACE1-like protease. The fragments produced by the action of these and other proteases on Nectin-1 can be used to diagnosis Alzheimer's Disease or a predilection towards Alzheimer's Disease.
FEDEROFF HOWARD [US]; LIM SEUNG T [US]
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