Process and Apparatus for Ion Channel Characterization
The present invention provides a process and an apparatus for performing the process, for ion channel characterisation, especially for determination of the impact of effector compounds onto the ion channel activity. For measuring, ion channels are comprised in lipid membrane vesicles. For detection, the generation or change of an optically detectable signal, e.g. of a dye like a colorimetrically detectable or a fluorescent compound, in dependency from the gating activity of the ion channel is used. The gating activity of permeation through the ion channel is initiated or triggered by applying a temperature shift, preferably as a rise in temperature from a low temperature of about 0 to 5 DEG to an elevated temperature.
ZEILINGER CARSTEN [DE]
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