Method for the Stereoselective Synthesis of Phosphorus Compounds
The present invention relates to a method for the stereoselective synthesis of phosphorus compounds, wherein in the first reaction step a chiral auxiliary is covalently bound to the phosphorus atom of phosphoryl chloride, thiophosphoryl chloride or phosphorus trichloride, the product from the first reaction step in a subsequent step is reacted with an alcohol, thiol or amine as a nucleophile in the presence of a base, and in the last step the chiral auxiliary is displaced from the product of the subsequent step by a nucleophile.
Patents:DE 112,009,001,327
Inventor(s):
MEIER CHRIS [DE]; THOMANN JENS [IE]
Type of Offer:
Sale
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