Universal Methylation Profiling Methods
This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransf erase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns. This invention also provides neobases and methods of sequencing for methylation patterns using neobases.
BESTOR TIMOTHY H [US]; EDWARDS JOHN R [US]; JU JINGYUE [US]; LI XIAOXU [US]
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