Osteochondral Implants, Arthroplasty Methods, Devices, and Systems
Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.
HUNG CLARK T [US]; ATESHIAN GERARD A [US]; LIMA ERIC G [US]; COOK JAMES L [US]; BIAN LI MING [US]
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