Self-assembling Multicellular Bodies and Methods of Producing a Three-dimensional Biological Structure Using the Same
Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion.; Methods of producing multicellular bodies having characteristics that facilitate assembly of the three-dimensional constructs are also provided.
FORGACS GABOR [US]; MARGA FRANCOISE SUZANNE [FR]; NOROTTE CYRILLE [FR]
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