Glur2 Receptor Modulators
The present invention provides for compositions and methods for modulating the GluR2 receptor. It is based, at least in part, on the discovery, by X- ray crystallography, that a known GluR2 agonist binds to the receptor in two different orientations, thereby diminishing its potency. The present invention provides for structural alternatives in which alternative binding possibilities are substantially eliminated.
GOUAUX JAMES ERIC [US]; SONG LANGZHOU [US]; XIE YULI [CN]; LANDRY DONALD W [US]
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