Dna Integrity Assay (dia) for Cancer Diagnostics, Using Confocal Fluorescence Spectroscopy
The present invention relates, e.g., to a method for determining the size distribution of DNA molecules in a sample comprising cell-free nucleic acid, comprising labeling the DNA with a fluorescent dye in a stoichiometric manner, subjecting the DNA to molecular spectroscopy (e.g., cylindrical illumination confocal spectroscopy), analyzing suitable fluorescent burst parameters of the labeled DNA, and conducting single molecule DNA integrity analysis of the labeled DNA molecules in the sample. In one embodiment of the invention, the method is used as a diagnostic method for detecting cancer.
WANG TZA-HUEI [US]; LIU KELVIN J [US]; SHIH IE-MING [US]
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