Method of manufacture of 1,3-dioxolane and 1,3-oxathiolane nucleosides
Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.
CLEARY DARRYL [US]; SORIA JOSE [US]; PAINTER GEORGE R [US]; LIOTTA DENNIS C [US]; ALMOND MERRICK [US]; SZNAIDMAN MARCOS L [US]
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