Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods of Preparing Same, and Methods for their Use

Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases, such as inflammation and neurodegenerative disorders. Also provided herein are methods of treating and preventing cancer and other Hsp90 related disease. The methods include administering to a subject a therapeutically effective amount of an Hsp90 inhibitor.

Attached files:
WO 2010042489.jpg

Patents:
WO 2,010,042,489

Inventor(s): SUN AIMING [US]; GANESH THOTA [US]; MIN JAEKI [US]; THEPCHATRI PAHK [US]; DU YUHONG [US]; SNYDER JAMES P [US]; LIOTTA DENNIS C [

Type of Offer: Licensing



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