Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods of Preparing Same, and Methods for their Use
Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases, such as inflammation and neurodegenerative disorders. Also provided herein are methods of treating and preventing cancer and other Hsp90 related disease. The methods include administering to a subject a therapeutically effective amount of an Hsp90 inhibitor.
SUN AIMING [US]; GANESH THOTA [US]; MIN JAEKI [US]; THEPCHATRI PAHK [US]; DU YUHONG [US]; SNYDER JAMES P [US]; LIOTTA DENNIS C [
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