Methods of Preparing 1-deoxy-sphingoid Bases and Derivatives Thereof
Novel methods of synthesizing 1-deoxy-sphingoid bases and derivatives are disclosed. The synthesis is achieved from commercially available and inexpensive starting materials. The process includes thioesterification, cross-coupling, and reduction. The process may also include directed epoxidation, regioselective epoxide-opening, hydrogenation, and dihydroxylation. The methods described herein provide 1-deoxy-sphingoid bases and derivatives in high overall yield and high enantiomeric purity.
LIEBESKIND LANNY S [US]; GARNIER-AMBLARD ETHEL C [US]; LIOTTA DENNIS C [US]
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