BHC80 - Histone Complexes and Uses Thereof
Provided herein is the tertiary structure of domains of the BHC80 protein, including the PHD finger domain, such as when the BHC80 protein is complexed with an unmodified histone H3 tail in the presence of zinc. The invention provides structural and functional information for use in the identification and design of compounds that agonize, antagonize or otherwise regulate enzyme (e.g., demethylase) activity, and to the compounds identified by such methods and the research, diagnostic and therapeutic uses of such compounds.
WO 2,009,015,283 [MORE INFO
SHI YANG [US]; LAN FEI [US]; CHENG XIAODONG [US]; COLLINS ROBERT E [US]; HORTON JOHN R [US]
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