2'-fluoronucleosides

The 2'-fluoronucleoside is provided to treat hepatitis type B, hepatitis type C, HIV(human immunodeficiency virus), and abnormal cell proliferation including tumor and cancer. The pharmaceutical composition for treating hepatitis type B in human comprises the 2'-fluoro-beta-D-nucleoside represented by the chemical formula or pharmaceutically acceptable salts thereof, wherein the base is purine; R^1 is OH, H, OR^3, N3, CN, halogen, CF3, C1-C4 alkyl, amino, C1-C4 alkyl amino or di(C1-C4) alkyl amino; R^2 is H, monophosphate, diphosphate, triphosphate; or carboxylic acid ester in which the non-carbonyl part of ester is selected from C1-C10 alkyl, C1-C10 alkoxy C1-C10 alkyl, arC1-C10 alkyl, aryloxy C1-C10 alkyl and aryl; R^3 is carboxylic acid ester in which the non-carbonyl part of ester is selected from C1-C10 alkyl, C1-C10 alkoxy C1-C10 alkyl, arC1-C10 alkyl, aryloxy C1-C10 alkyl and aryl; C1-C10 alkyl or phosphate.

Attached files:
KR 20090009338.jpg

Patents:
KR 20,090,009,338   [MORE INFO]

Inventor(s): SCHINAZI RAYMOND F [US]; LIOTTA DENNIS C [US]; CHU CHUNG K [US]; MCATEE J JEFFREY [US]; SHI JUNXING [CN]; CHOI YONG SEOK [US]; L

Type of Offer: Licensing



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