Non-myelosuppressive Compounds, Pharmaceutical Compositions Thereof, and Methods of Treatment

The present invention provides microtubule targeting compounds that are myelo-sparing. Particularly, the MTCs of the invention are structurally designed to exhibit specificity for inhibiting ss-tubulin isotypes that are not related to the myelosuppression associated with other known MTCs. The invention further provides pharmaceutical compositions incorporating the inventive MTCs and methods of treating cancer using the MTCs. The invention still further provides various assays for identifying myelo-sparing compounds and determining whether such compounds are indicated for use with specific patients.

Patents:
WO 2,009,146,152

Inventor(s): SNYDER JAMES P [US]; ALCARAZ ANA A [US]; KINGSTON DAVID GEORGE IAN [US]; CHEN QIAO-HONG [US]; GANESH THOTA [US]; GIANNAKAKOU PAR

Type of Offer: Licensing



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