Compositions and Methods for the Treatment of Infections and Tumors.

PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD- 1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated using PD-1 antagonists. In addition, subjects with tumors can be treated using the PD-1 antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-1 antagonist.

Patents:
MX 2,009,006,786

Inventor(s): AHMED RAFI [US]; SHARPE ARLENE; AMARA RAMA; FREEMAN GORDON

Type of Offer: Licensing



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