The present invention relates to anti-flavivirus compounds, including lycorine and derivatives thereof, and their use in treating a subject infected by a flavivirus. The present invention also relates to the use of the anti-flavivirus compounds for the prophylaxis of flavivirus infection. The present invention further relates to a method of suppressing viral RNA synthesis of a flavivirus. Also described is a method of preparing an anti-flavivirus compound for use in the treatment or prophylaxis of flavivirus infection.
SHI PEI-YONG [US]; PUIG-BASAGOITI FRANCESC [US]; PANKIEWICZ KRZYSZTOF W [US]; FELCZAK KRZYSZTOF [US]; CHEN LIQIANG [US]
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