Biologically Active Molecules, Particularly Based on PNA and siRNA, Method for the Cell-specific Activation Thereof, and Application Kit to Be Administered
Biologically active molecules are inactivated for selective activation by target cells by being covalently bonded to one or more peptides each of which has one or more specific amino acid sequences that are selected in respect of enzymes cell-specific for target cells. The bonds, which are broken exclusively by the enzymes cell-specific for the target cells in order to biologically activate the molecules, allow the molecules to remain biologically inactive in cells other than the target cells. The molecules are used for influencing gene expression of preferably sick and infected organs or cells, for example.
US 2,010,009,446 [MORE INFO
POEHLMANN TOBIAS [DE]; SEYFARTH LYDIA [DE]
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