Selective Aliphatic C-H Oxidation
A composition including a complex of a metal, a tetradentate ligand, at least one ancillary ligand, and a counterion may be used for selective sp3 C-H bond oxidation. The tetradentate ligand may include a N-heterocyclic-N,N'-bis(pyridyl)-ethane-1,2-diamine group or a N,N'-bis(heterocyclic)-N,N'-bis(pyridyl)-ethane-1,2-diamine group. The composition can be used in combination with H2O2 to effect highly selective oxidations of unactivated sp3 C-H bonds over a broad range of substrates. The site of oxidation can be predicted, based on the electronic and/or steric environment of the C-H bond. In addition, the oxidation reaction does not require the presence of directing groups in the substrate.
WHITE M CHRISTINA [US]; CHEN MARK S [US]
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