Method for the Synthesis of A-ring Aromatized Acetyl Minocyclines
The invention relates to a process for production of A-ring aromatized acetyl-minocycline.The object of the invention, a resource-light process for the production of A-ring aromatized acetyl-Minocycline Formula $ F1 where R <1> to R <5> = acetyl and / or H to provide, it is also feasible on an industrial scale , is solved by the fact that minocycline hydrochloride reacted with acetic anhydride in the presence of a proton scavenger, the reaction product of a chromatographic purification using a carrier material and subjected to an eluent, the eluentdistilled off and the product is then purified by recrystallization.
LORENZ PETER [DE]; KREUTZMANN PETER [DE]; ROTHE FRITZ [DE]; MARTENS-LOBENHOFFER JENS [DE]; SCHMIDT HARRY [DE]; WOLF GERALD [DE]
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