Method for the Synthesis of A-ring Aromatized Acetyl Minocyclines
The invention relates to a method for the production of A-ring aromatized acetyl minocyclines. The aim of the invention to provide a less complex method for the production of A-ring aromatized acetyl minocyclines of the formula (I), wherein R1 to R5 = acetyl and/or H, which can also be used on an industrial scale, is achieved in that minocycline hydrochloride is reacted with acetanhydride in the presence of a proton catcher, the reaction product is subjected to chromatographic filtration using a carrier material and an eluant, the eluant is distilled off, and the product is subsequently cleaned by recrystallization.
LORENZ PETER [DE]; KREUTZMANN PETER [DE]; ROTHE FRITZ [DE]; MARTENS-LOBENHOFFER JENS [DE]; SCHMIDT HARRY [DE]; WOLF GERALD [DE
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