Method for the Synthesis of A-ring Aromatized Acetyl Minocyclines

The invention relates to a method for the production of A-ring aromatized acetyl minocyclines. The aim of the invention to provide a less complex method for the production of A-ring aromatized acetyl minocyclines of the formula (I), wherein R1 to R5 = acetyl and/or H, which can also be used on an industrial scale, is achieved in that minocycline hydrochloride is reacted with acetanhydride in the presence of a proton catcher, the reaction product is subjected to chromatographic filtration using a carrier material and an eluant, the eluant is distilled off, and the product is subsequently cleaned by recrystallization.

Attached files:
2009012741.jpg

Patents:
WO 2,009,012,741

Inventor(s): LORENZ PETER [DE]; KREUTZMANN PETER [DE]; ROTHE FRITZ [DE]; MARTENS-LOBENHOFFER JENS [DE]; SCHMIDT HARRY [DE]; WOLF GERALD [DE

Type of Offer: Sale



Next Patent »
« More Chemistry Patents
« More Crystallography Patents

Share on      


CrowdSell Your Patent