Uses of Bispecific Antibody Coated Dendritic Cells Pulsed with Antigens and GM-CSF in Immune Regulation

GM-CSF administered before immunization exerted a sustained suppressive effect against the induction of myasthenia gravis (MG). This suppression was associated with lowered serum autoantibody levels, reduced T cell proliferative responses to AChR, and an expansion in the population of FoxP3+ regulatory T cells. Manipulating DCs to expand regulatory T cells is useful for the control of autoimmune diseases such as myasthenia gravis MG.

Patents:
US 20,090,232,854   [MORE INFO]

Inventor(s): PRABHAKAR BELLUR S [US]; HOLTERMAN MARK J [US]; VASU CHENTHAMARAKSHAN [US]; MERIGGIOLI MATTHEW N [US]

Type of Offer: Licensing



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