Neutralization of Staphylococcal and Streptococcal Toxins
Staphyloccocus and Streptococcus bacteria secrete various toxins that act as superantigens by stimulating a large fraction of the host's T cells. The binding of toxins to the variable domains of T cell receptor ss chains (Vss) leads to massive release of inflammatory molecules and, potentially, toxic shock syndrome (TSS). Soluble forms of different Vss domains able to bind superantigens with high-affinity have previously been generated. However, to neutralize unknown toxins or multiple toxins a broader spectrum antagonist is required. The present invention expresses multiple Vss domains in tandem as a single-chain protein and neutralizes the clinically important superantigens, particularly staphylococcal enterotoxin B and TSS toxin-1, with a single agent.
KRANZ DAVID M [US]; BUONPANE REBECCA A [US]; YANG XI [US]; SCHLIEVERT PATRICK M [US]
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