Oligonucleotide Specific Uptake of Nanoconjugates
Disclosed are nanoparticles functionalized with an oligonucleotide and a domain, wherein the domain increases cellular uptake of the nanoparticles. The domain is a sequence of nucleobases or phosphate groups, such as a poly thymidine (polyT) sequence or a phosphate polymer (C3 residue) and may be located 5' to the oligonucleotide, 3' to the oligonucleotide, within, or colinear with the oligonucleotide. Usage of the nanoparticles including modulating gene regulation is contemplated.
MIRKIN CHAD A [US]; GILJOHANN DAVID A [US]
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