Controlled Agent Release and Sequestration
Disclosed are nanostructures having nanoprisms and agents, such as diagnostic and/or therapeutic agents. Nanoprisms with a surface plasmon resonance in the near-infrared convert irradiation, such as from a laser into heat selectively to allow the dissociation, such as dehybridization of oligonucleotide duplexes, of agents associated with the nanoprism surface. These nanostructures show morphological, chemical, and functional stability under hours of irradiation. Further disclosed are methods of selectively releasing agents from nanostructures after directed surface plasmon resonance mediated heating of the nanoprisms. Released agents, such as oligonucleotides, are unharmed by this process and can be repeatedly released and sequestered under spatiotemporal control.
MIRKIN CHAD A [US]; JONES MATTHEW R [US]; MILLSTONE JILL E [US]; GILJOHANN DAVID A [US]; SEFEROS DWIGHT S [CA]; YOUNG KAYLIE L [
Type of Offer:
« More Nanotech Patents