Novel Retinamide Retinoic Acid Metabolism Blocking Agents

Retinoic acid metabolism blocking agents (RAMBAs). The RAMBAs may be used for treatment of cancer, including breast and prostate cancers. Methods for preparing novel retinamide RAMBAs. The methods include reacting RAMBAs with terminal polar carboxylic acid group with a variety of amines in the presence of suitable coupling reagents. The retinamide RAMBAs are potent inhibitors of the growth of prostate and breast cancer cells and may be useful for the treatment of these diseases in humans.

Patents:
US 20,110,059,974

Inventor(s): NJAR VINCENT C O [US]; GEDIYA LALJI K [US]; KHANDELWAL AAKANKSHA [US]

Type of Offer: Licensing



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