Co-signaling Methods for Treating Cancers

Provided herein is a method of treating a neoplastic disease in an individual in need of such treatment, comprising the steps of: expanding ?d T lymphocytes in vitro; priming Natural Kill cells in vitro; and administering said expanded ?d T lymphocytes and said primed Natural Kill cells to said individual, thereby resulting in a cytotoxic or cytolytic effect. Further provided is a method of treating a neoplastic disease in an individual in need of such treatment, comprising the steps of: administering a compound to said individual that activates yd T lymphocytes; and administering an antibody directed against a tumor antigen associated with said neoplastic disease.

Patents:
WO 2,010,141,093

Inventor(s): STROME SCOTT E [US]; SCHULZE DAN H [US]; CHAPOVAL ANDREI [US]

Type of Offer: Licensing



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