Methods for Treating Cancers and Diseases Associated with 4-1BB (CD137) Expression
The present invention relates to the role of 4-1BB (CD137) ligand and anti-4-1BB (CD137) antibody in the treatment of cancers and diseases associated with 4-1BB (CD137) expression. More particularly, the present invention relates to the use of (i) 4-1BB (CD137) ligand for inducing proliferation and activation and promoting survival of B lymphocytes and (2) anti-4-1BB (anti-CD137) antibody for inhibiting proliferation and activation and inducing death of B lymphocytes.
WO 2,010,132,389 [MORE INFO
STROME SCOTT [US]; ZHANG XIAOYU [US]
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