ZAP-70 As Predictor and Modulator of Effector Function of T Cells
In this application is described a novel, multiparameter analysis of TCR-coupled signaling and function in resting and activated naive and memory CD4 T cells, revealing a biochemical basis for immunological recall. Results reveal a novel biochemical signature imparted to memory CD4 T cells enabling efficacious responses through increased ZAP-70 expression and reduced accumulation of downstream signaling events.
WO 2,009,035,600 [MORE INFO
FARBER DONNA L [US]; CHANDOK MEENA [US]; OKOYE FRANSESCA L [US]
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