Compositions and Methods Utilizing Fibrin Beta Chain Fragments of the Bbeta Chain of Fibrinogen
A composition including a peptide sequence of the formula ssX1-X2, the peptide sequence corresponding to an amino acid sequence of a fibrin beta chain fragment of a Bbeta chain of fibrinogen, wherein X1 represents an N-terminal end of the peptide sequence, and X2 represents a C-terminal end of the peptide sequence, wherein the peptide sequence includes additional amino acids between X1 and X2, wherein the peptide sequence may contain a non-naturally occurring amino acid residue, wherein the peptide sequence is other than a wild-type ss15-42 monomer sequence per se, and wherein the peptide sequence is other than (ss15-66)2 dimer having two chains with each chain limited to wild type amino acids ss15-65 and each chain further including a non-naturally occurring Gly at position 66 of each chain.; Methods for treatment and pharmaceutical combinations may include a polypeptide agent such as Thymosin beta 4. In such methods and combinations, a dimer of the peptide sequence may include amino acids 15-66 of the fibrin beta chain.
MEDVED LEONID [US]; ZHANG LI [US]; YAKOVLEV SERGIY [US]; GOLDSTEIN ALLAN L [US]; CROCKFORD DAVID [US]
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