SHIP-Deficiency to Increase Megakaryocyte Progenitor Production
The invention concerns a method for increasing megakaryocyte and megakaryocyte progenitor numbers in vitro or in vivo by suppressing SH2-containing inositol-5-phosphatase (SHIP) function in megakaryocytes or megakaryocyte progenitors expressing the SHIP gene. SHIP function can be suppressed by administering an interfering RNA, or other SHIP inhibitor, to the megakaryocytes or megakaryocyte progenitors in vitro or in vivo.
KERR WILLIAM G [US]; DESPONTS CAROLINE [US]; PEREZ LIA ELENA [US]
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