Antiviral Activity of Cyclopentene Nitro-ester and Derivatives

Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (>99% ee) was influenced by desymmetrization catalyzed by Pseudomonas cepacia lipase and the stereo selective nature of the palladium catalyzed transformations.

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Patents:
US 20,100,249,230

Inventor(s): BISHT KIRPAL S [US]; VAN OLPHEN ALBERTO [US]; KHAN PASHA M [US]; BUCHER CYNTHIA [US]

Type of Offer: Licensing



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