Indoline Scaffold Shp-2 Inhibitors and Method of Treating Cancer
Protein tyrosine phosphatase (PTP) Shp2 is a non-receptor PTP that involved in cell signaling and regulation of cell proliferation, differentiation, and migration. Shp2 mediates activation of kinases that are involved in the pathogenesis of human carcinoma. A high throughput screen identified compounds that inhibit the PTP Shp2. Several compounds were identified that selectively inhibit Shp2 over Shp1 with low to sub-micromolar activity. Also disclosed are methods of inhibiting a protein tyrosine phosphatase in a cell and treating cancer through selective inhibition of Shp2.
WU JIE [US]; LAWRENCE NICHOLAS JAMES [US]; SEBTI SAID M [US]; LAWRENCE HARSHANI RITHMA [US]
Type of Offer:
« More Biotech Patents