Materials and Methods for Preventing Or Treating Neurodegenerative Conditions Associated with Abeta Peptide Accumulation
The subject invention concerns methods for preventing and/or treating neurodegenerative conditions associated with Abeta peptide accumulation in neural tissue in a human or animal. The subject invention also concerns methods for preventing or treating Alzheimer's disease-like neuropathology in a person or animal having trisomy 21 (Down's syndrome). In one embodiment, a method of the invention comprises administering a therapeutically effective amount of a compound that inhibits function or activity of a Raf protein to a person or animal in need of treatment. In a specific embodiment, the Raf inhibitor is Sorafenib (NEXAVAR). Neurodegenerative conditions contemplated within the scope of the present invention include, for example, Alzheimer's disease and Parkinson's disease.; The subject invention also concerns methods for preventing or inhibiting neuronal cell death and/or improving cell viability.
ECHEVERRIA MORAN VALENTINA [US]; ARENDASH GARY W [US]
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