Method of Selectively Inhibiting PKCiota

PKCiota inhibitor1 H-imidazole-4-carboxamide, 5-amino-1 -[2,3-dihydroxy-4-[(phosphonooxy) methyl] cyclopentyl] -,[1 R-(1a, 2ss, 3 ss, 4 a)], (ICA-1 ), targets a unique sequence (amino acid residues 469-475) in the catalytic domain of PKCiota and inhibits PKCiota activity. The data shows suprising and unexpected ability of ICA-1 to slectively inhibit the proliferation of cells that overexpress PKCiota.

Attached files:
WO 2009036414.jpg

Patents:
WO 9,351,981 issued 2016-05-31   [MORE INFO]

Inventor(s): ACEVEDO-DUNCAN MILDRED [US]; DESAI SHRADDHA R [US]; WIN HLA YEE [US]; PILLAI PRAJIT P [US]; HILL DIONDRA D [US]; OSTROV DAVID A

Type of Offer: Licensing



Next Patent »
« More Biotech Patents

Share on      


CrowdSell Your Patent