Method of Selectively Inhibiting PKCiota
PKCiota inhibitor1 H-imidazole-4-carboxamide, 5-amino-1 -[2,3-dihydroxy-4-[(phosphonooxy) methyl] cyclopentyl] -,[1 R-(1a, 2ss, 3 ss, 4 a)], (ICA-1 ), targets a unique sequence (amino acid residues 469-475) in the catalytic domain of PKCiota and inhibits PKCiota activity. The data shows suprising and unexpected ability of ICA-1 to slectively inhibit the proliferation of cells that overexpress PKCiota.
WO 9,351,981 issued 2016-05-31 [MORE INFO
ACEVEDO-DUNCAN MILDRED [US]; DESAI SHRADDHA R [US]; WIN HLA YEE [US]; PILLAI PRAJIT P [US]; HILL DIONDRA D [US]; OSTROV DAVID A
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