Acylsulfonamides and Processes for Producing the Same

The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.

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Patents:
WO 8,524,947 issued 2013-09-03   [MORE INFO]

Inventor(s): MANETSCH ROMAN [US]; WANG HONG-GANG [US]; HU XIANDONG [US]; KULKAMI SAMEER [US]; SUN JIAZHI G [US]

Type of Offer: Licensing



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