Use of SH2 STAT3/STAT1 Peptidomimetics as Anticancer Drugs
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention display selective inhibition of specific STAT isoform homo-dimerization. The peptidomimetic probes of STAT1 function, described herein, provide the means to preferentially inhibit STAT1 over STAT3 through the exploration of the C-terminus.
SEBTI SAID M [US]; HAMILTON ANDREW D [US]; TURKSON JAMES [US]; JOVE RICHARD [US]
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