The present invention relates, in general, to HIV-1 specific antibodies and, in particular, to broadly neutralizing HIV-1 specific antibodies that target the gp41 membrane-proximal external region (MPER). The present invention also relates to a cell culture system, more specifically, to a method of rendering chronic lymphocytic leukemia B-cells immortal and to a method of isolating anti-viral antibodies from clones of such cells.
WO 2,011,034,582 [MORE INFO
HAYNES BARTON F [US]; TOMARAS GEORGIA [US]; SHEN SHAUNNA [US]; DIMITROV DIMITER S [US]; ZHU ZHONGYU [US]; HWANG KWAN-KI [US]; CH
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