Methods for Modulating Immune Responses to AAV Gene Therapy Vectors

The present disclosure provides methods of inhibiting an immune response to a viral vector used in gene therapy, such as adeno-associated virus (AAV), which involves co-administration of viral vector and an interfering molecule. The interfering molecule functions by either disrupting the TLR9-MyD88-type I IFN signaling pathway and/or neutralizing Type I IFNs, thereby inhibiting the immune response directed against the viral vector. The methods additionally encompass the step of re-administering the viral vector.

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Patents:
US 20,110,070,241   [MORE INFO]

Inventor(s): YANG YIPING [US]

Type of Offer: Licensing



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