Biodegradable Copolymer Comprising Amylopectin Or Glycogen Suitable for Delivering Nucleic Acid Materials Into Cells
The invention is related to a biodegradable copolymer, which is suitable for delivering nucleic acid materials into cells, and which comprises a amylopectin or glycogen and at least one cationic polymer or cationic monomer having amino functions, which is bound to the amylopectin or glycogen by ester linkage between at least one free hydroxyl group of the amylopectin or glycogen and at least one amino group of the cationic polymer or cationic monomer forming an -O-C=O-NH- bond. The biodegradable copolymer is capable of delivering nucleic acid molecules into the cells in a high efficient way with extremely low cytotoxicity.
WANG WEIWEI [DE]; LI WENZHONG [DE]; MA NAN [DE]; STEINHOFF GUSTAV [DE]
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