Substituted Porphyrins

Discloses are compounds according to Formula I. Further provided are methods of reducing oxidative stress in a cell, methods of treating a disease including cancer, and methods of treating a subject with a disorder associated with oxidative stress, the methods including administering a compound according to the invention. Also disclosed are methods of potentiating a cancer cell for treatment with ionizing radiation or chemotherapeutics including contacting the cell with an effective amount of a compound according to the invention. Further discloses are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a compound according to the invention.

Attached files:
WO 2010080881.jpg

Patents:
WO 2,010,080,881

Inventor(s): BATINIC-HABERLE INES [US]; REBOUCAS JULIO S [BR]; SPASOJEVIC IVAN [US]

Type of Offer: Licensing



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